Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Because of its impact on multiple biological pathways, heparanase has emerged as a major
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …

Background The endoglycosidase heparanase which degrades heparan sulfate
proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders …

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS), facilitating
degradation of the extracellular matrix (ECM) and the release of HS-bound biomolecules …

In recent years, heparanase has attracted considerable attention as a promising target for
innovative pharmacological applications. Heparanase is a multifaceted protein endowed …

Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …

Heparanase, the sole heparan sulfate (HS)-degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

Heparan sulphate (HS) polysaccharides are covalently attached to the core proteins of
various proteoglycans at cell surfaces and in the extracellular matrix. They are composed of …

Heparan sulfate (HS) proteoglycans at the cell surface and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and are implicated in disease …