Cholinergic nervous system and glaucoma: From basic science to clinical applications

MA Faiq, G Wollstein, JS Schuman, KC Chan - Progress in retinal and eye …, 2019 - Elsevier
The cholinergic system has a crucial role to play in visual function. Although cholinergic
drugs have been a focus of attention as glaucoma medications for reducing eye pressure …

Therapeutic drugs and devices for tackling ocular hypertension and glaucoma, and need for neuroprotection and cytoprotective therapies

NA Sharif - Frontiers in pharmacology, 2021 - frontiersin.org
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress

ML Cooper, S Pasini, WS Lambert… - Proceedings of the …, 2020 - National Acad Sciences
In the central nervous system, glycogen-derived bioenergetic resources in astrocytes help
promote tissue survival in response to focal neuronal stress. However, our understanding of …

Transneuronal degeneration in the brain during glaucoma

M You, R Rong, Z Zeng, X Xia, D Ji - Frontiers in aging neuroscience, 2021 - frontiersin.org
The death of retinal ganglion cells (RGCs) is a key factor in the pathophysiology of all types
of glaucoma, but the mechanism of pathogenesis of glaucoma remains unclear. RGCs are a …

Retinal structures and visual cortex activity are impaired prior to clinical vision loss in glaucoma

MC Murphy, IP Conner, CY Teng, JD Lawrence… - Scientific reports, 2016 - nature.com
Glaucoma is the second leading cause of blindness worldwide and its pathogenesis
remains unclear. In this study, we measured the structure, metabolism and function of the …

[HTML][HTML] Citicoline modulates glaucomatous neurodegeneration through intraocular pressure-independent control

Y van der Merwe, MC Murphy, JR Sims, MA Faiq… - …, 2021 - Elsevier
Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss.
Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma …

In vivo imaging of structural, metabolic and functional brain changes in glaucoma

A Kasi, MA Faiq, KC Chan - Neural Regeneration Research, 2019 - journals.lww.com
Glaucoma, the world's leading cause of irreversible blindness, is a condition for which
elevated intraocular pressure is currently the only modifiable risk factor. However, the …

[HTML][HTML] Defining functional requirements for a patient-centric computerized glaucoma treatment and care ecosystem

N Goldmann, SE Skalicky, RN Weinreb… - Journal of Medical …, 2023 - jmai.amegroups.org
Background: Glaucoma is a group of chronic diseases that cause progressive damage to the
optic nerve, resulting in irreversible and potentially debilitating visual loss. A unified …

Axon hyperexcitability in the contralateral projection following unilateral optic nerve crush in mice

NR McGrady, JM Holden, M Ribeiro… - Brain …, 2022 - academic.oup.com
Optic neuropathies are characterized by degeneration of retinal ganglion cell axonal
projections to the brain, including acute conditions like optic nerve trauma and progressive …

Widespread brain reorganization perturbs visuomotor coordination in early glaucoma

V Trivedi, JW Bang, C Parra, MK Colbert… - Scientific reports, 2019 - nature.com
Glaucoma is the world's leading cause of irreversible blindness, and falls are a major public
health concern in glaucoma patients. Although recent evidence suggests the involvements …