Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?

Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

Living leukocyte‐based drug delivery systems

Y Chen, D Qin, J Zou, X Li, XD Guo, Y Tang… - Advanced …, 2023 - Wiley Online Library
Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

Bioactive nanoenzyme reverses oxidative damage and endoplasmic reticulum stress in neurons under ischemic stroke

G Huang, J Zang, L He, H Zhu, J Huang, Z Yuan… - ACS …, 2021 - ACS Publications
Designing translational antioxidative agents that could scavenge free radicals produced
during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main …

The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

J Liu, Z Liu, Y Pang, H Zhou - Journal of Nanobiotechnology, 2022 - Springer
Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of
different materials and adjustment of their physical and chemical properties, nanoparticles …

Targeted treatment of ischemic stroke by bioactive nanoparticle-derived reactive oxygen species responsive and inflammation-resolving nanotherapies

J Yuan, L Li, Q Yang, H Ran, J Wang, K Hu, W Pu… - ACS …, 2021 - ACS Publications
Stroke is a primary cause of death and disability worldwide, while effective and safe drugs
remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle …

[HTML][HTML] Nanomedicine for acute respiratory distress syndrome: the latest application, targeting strategy, and rational design

Q Qiao, X Liu, T Yang, K Cui, L Kong, C Yang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation
and destruction of the lung air–blood barrier, leading to irreversible and substantial …

Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm

YY Lee, HH Park, W Park, H Kim, JG Jang, KS Hong… - Biomaterials, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of
coronavirus not previously identified in humans. Globally, the number of confirmed cases …

[HTML][HTML] Advanced hitchhiking nanomaterials for biomedical applications

Y Wang, SK Sun, Y Liu, Z Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Hitchhiking, a recently developed bio-inspired cargo delivery system, has been harnessed
for diverse applications. By leveraging the interactions between nanoparticles and …

Dysregulation of neutrophil death in sepsis

C Zhu, Y Wang, Q Liu, H Li, C Yu, P Li, X Deng… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a prevalent disease that has alarmingly high mortality rates and, for several
survivors, long-term morbidity. The modern definition of sepsis is an aberrant host response …

Ligustrazine nanoparticle hitchhiking on neutrophils for enhanced therapy of cerebral ischemia‐reperfusion injury

Q Mu, K Yao, MZ Syeda, M Zhang, Q Cheng… - Advanced …, 2023 - Wiley Online Library
Ischemic stroke is a refractory disease that endangers human health and safety owing to
cerebral ischemia. Brain ischemia induces a series of inflammatory reactions. Neutrophils …