Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the
chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types …

Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …

Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The
increase in the number of sublining macrophages in the synovium is an early hallmark of …

The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its
association with the progression of cancer. Although first described as a chemotactic …

Objectives While various monocyte chemokine systems are increased in expression in
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid
arthritis. The study of synovial tissue has advanced considerably throughout the past few …