Antibiotic resistance is increasing in pathogenic microbial populations and is thus a major
threat to public health. The fate of a resistance mutation in pathogen populations is …

Most antibiotic resistance mechanisms are associated with a fitness cost that is typically
observed as a reduced bacterial growth rate. The magnitude of this cost is the main …

A key parameter influencing the rate and trajectory of the evolution of antibiotic resistance is
the fitness cost of resistance. Recent studies have demonstrated that antibiotic resistance …

Microbiology research has recently undergone major developments that have led to great
progress towards obtaining an integrated view of microbial cell function. Microbial genetics …

Reactive oxygen species (ROS) produced as a secondary effect of bactericidal antibiotics
are hypothesized to play a role in killing bacteria. If correct, ROS may play a role in …

The ribosome is one of the main antibiotic targets in the cell. Recent years brought important
insights into the mode of interaction of antibiotics with the ribosome and mechanisms of …

Deformylase inhibitors belong to a novel antibiotic class that targets peptide deformylase, a
bacterial enzyme that removes the formyl group from N-terminal methionine in nascent …

Colistin resistance in Acinetobacter baumannii, a pathogen of clinical concern, was induced
in the susceptible strain ATCC 19606 by growth under increasing pressure of the antibiotic …

Small-colony variants (SCVs) of Staphylococcus aureus are a slow-growing subpopulation
whose phenotypes can include resistance to aminoglycosides, defects in electron transport …

Campylobacter and Salmonella are the most commonly reported bacterial causes of human
foodborne infections, and increasing proportions of these pathogens become resistant to …