The identification of actionable tumor antigens is indispensable for the development of
several cancer immunotherapies, including T cell receptor–transduced T cells and patient …

Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …

Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …

Features of the cancer epigenome distinguish cancers from their respective cell of origin and
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …

Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of
cancer patients. Recent evidence suggests that epigenetic therapies synergize with …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

We analyze transposable elements (TEs) in glioblastoma (GBM) patients using a
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing …

Our defenses against infection rely on the ability of the immune system to distinguish
invading pathogens from self. This task is exceptionally challenging, if not seemingly …

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy resulting
from overproduction of immature T-cells in the thymus and is typified by widespread …