Autoimmune hepatitis

G Mieli-Vergani, D Vergani, AJ Czaja… - Nature Reviews …, 2018 - nature.com
Autoimmune hepatitis (AIH) is a severe liver disease that affects children and adults
worldwide. The diagnosis of AIH relies on increased serum transaminase and …

Regulatory T cells (Tregs) and their therapeutic potential against autoimmune disorders–Advances and challenges

TK Goswami, M Singh, M Dhawan, S Mitra… - Human vaccines & …, 2022 - Taylor & Francis
Autoimmune diseases are caused when immune cells act against self-protein. This
biological self–non-self-discrimination phenomenon is controlled by a distinct group of …

Autoimmune hepatitis

BT Beretta-Piccoli, G Mieli-Vergani… - The Rose and Mackay …, 2024 - Elsevier
Autoimmune hepatitis (AIH) is an inflammatory liver disease, affecting mainly females,
characterized by elevated transaminase and immunoglobulin G (IgG) levels, interface …

[HTML][HTML] Autoimmune hepatitis–update 2015

MP Manns, AW Lohse, D Vergani - Journal of hepatology, 2015 - journal-of-hepatology.eu
Autoimmune hepatitis (AIH) was first described in 1951 [1] as a chronic hepatitis of young
women with hypergammaglobulinemia in the absence of cirrhosis, which responds well to …

Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

E Smirnova, MD Muthiah, N Narayan, MS Siddiqui… - Hepatology, 2022 - journals.lww.com
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

Immunity, tolerance and autoimmunity in the liver: A comprehensive review

DG Doherty - Journal of autoimmunity, 2016 - Elsevier
The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Regulatory T-cells in autoimmune diseases: challenges, controversies and—yet—unanswered questions

CR Grant, R Liberal, G Mieli-Vergani, D Vergani… - Autoimmunity …, 2015 - Elsevier
Regulatory T cells (Tregs) are central to the maintenance of self-tolerance and tissue
homeostasis. Markers commonly used to define human Tregs in the research setting include …

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells

AK Horst, K Neumann, L Diehl, G Tiegs - Cellular & molecular …, 2016 - nature.com
The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure
upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also …

The role of inflammation in autoimmune disease: a therapeutic target

Y Xiang, M Zhang, D Jiang, Q Su, J Shi - Frontiers in Immunology, 2023 - frontiersin.org
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …

[HTML][HTML] Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics

NK Gatselis, K Zachou, GK Koukoulis… - World journal of …, 2015 - ncbi.nlm.nih.gov
Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology
characterized by hypergammaglobulinemia, autoantibodies detection and interface …