Detection of minimal residual disease (MRD) has proven to provide independent prognostic
information for treatment stratification in several types of leukemias such as childhood acute …

Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia
patients have shown that large-scale MRD studies are feasible and that clinically relevant …

The AML1–CBFβ transcription factor is the most frequent target of chromosomal
rearrangements in human leukemia. To investigate its normal function, we generated mice …

Genome-wide chemical mutagenesis screens in the zebrafish (Danio rerio) have led to the
identification of novel genes affecting vertebrate erythropoiesis. In determining if this …

The major established cause of acute myeloid leukemia (AML) in the young is cancer
chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de …

VER A DECADE HAS passed since ''Immunologic Classification of Leukemia and
Lymphoma''by Foon and Todd was published in Blood. 1 Over this decade, flow Acute …

We have developed a multiplex reverse transcription-polymerase chain reaction (RT-PCR)
reaction, which enables us to detect 29 translocations/chromosomal aberrations in patients …

Core binding factor beta (CBF beta) is considered to be a transcriptional coactivator that
dimerizes with transcription factors core binding factor alpha 1 (CBFA1),-2, and-3, and …

The fusion oncogene CBFB–MYH11 is generated by a chromosome 16 inversion in human
acute myeloid leukemia subtype M4Eo. Mouse embryonic stem (ES) cells heterozygous for …

Multi-parameter flow cytometry, molecular genetics, and cytogenetic studies have all
contributed to new classification of leukemia. In this review we discuss immunophenotypic …