Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Pigments are present in all living matter and provide attractive colors and play basic roles in
the development of organisms. Human beings, like most animals, come in contact with their …

Abstract Molegro Virtual Docker is a protein-ligand docking simulation program that allows
us to carry out docking simulations in a fully integrated computational package. MVD has …

Advances in the flavonoid field have been nothing short of spectacular over the last 20
years. While the medical field has noticed flavonoids for their potential antioxidant …

Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

A significant number of drugs and drug candidates in clinical development are halogenated
structures. For a long time, insertion of halogen atoms on hit or lead compounds was …

Flavones and isoflavones may play a prominent role in cancer prevention since these
compounds are found in numerous plants that are associated with reduced cancer rates …

Protein kinases are targets for treatment of a number of diseases. This review focuses on
kinase inhibitors that are in the clinic or in clinical trials and for which structural information is …

Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in
traditional Chinese medicine to treat chronic diseases. Here we identify indirubin and its …

A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole
core (indolinones). Two compounds from this class inhibited the kinase activity of fibroblast …