Iron deficiency and immune activation are the two most frequent causes of anemia, both of
which are based on disturbances of iron homeostasis. Iron deficiency anemia results from a …

Cancer contributes to 50% of deaths worldwide and new anti-tumour therapeutics with novel
mechanisms of actions are essential to develop. Metabolic inhibitors represent an important …

Iron is an essential element and a critical component of molecules involved in energy
production, cell cycle and intermediate metabolism. However, the same characteristic …

It was hypothesized that contact between chronic lymphocytic leukaemia (CLL) B‐cells and
marrow stromal cells impact both cell types. To test this hypothesis, we utilized a long‐term …

Background & Aims: Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron
metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis …

Iron has a pivotal role in homeostasis due to its participation in virtually all of the body's
oxidationreduction processes. However, iron can also be considered a double-edged …

Iron is essential for cell growth and is imported into cells in part through the action of
transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and …

The voltage-dependent anion channel 1 (VDAC1), localized in the outer mitochondrial
membrane, mediates metabolic cross-talk between the mitochondrion and the cytoplasm …

Flow Cytometry of Hematological Malignancies Flow cytometric analysis is often integral to
the swift and accurate diagnosis of leukemias and lymphomas of the blood, bone marrow …

Endometriosis is associated with ovarian cancers, mainly endometrioid and clear-cell
carcinomas. Iron metabolism has been shown to play a role in endometriosis. Therefore, it is …