FDA-approved kinase inhibitors in preclinical and clinical trials for neurological disorders

A Lui, J Vanleuven, D Perekopskiy, D Liu, D Xu… - Pharmaceuticals, 2022 - mdpi.com
Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …

Multifaceted Roles of ALK Family Receptors and Augmentor Ligands in Health and Disease: A Comprehensive Review

L Katic, A Priscan - Biomolecules, 2023 - mdpi.com
This review commemorates the 10-year anniversary of the discovery of physiological ligands
Augα (Augmentor α; ALKAL2; Fam150b) and Augβ (Augmentor β; ALKAL1; Fam150a) for …

Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice

M Defaye, A Bradaia, NS Abdullah… - The Journal of …, 2024 - Am Soc Clin Investig
Inflammation and pain are intertwined responses to injury, infection, or chronic diseases.
While acute inflammation is essential in determining pain resolution and opioid analgesia …

Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection

E Granton, L Brown, M Defaye, P Moazen, H Almblad… - Cell, 2024 - cell.com
Infections of the lung cause observable sickness thought to be secondary to inflammation.
Signs of sickness are crucial to alert others via behavioral-immune responses to limit contact …

3D genomic features across> 50 diverse cell types reveal insights into the genomic architecture of childhood obesity

KB Trang, MC Pahl, JA Pippin, C Su, SH Littleton… - eLife, 2025 - elifesciences.org
The prevalence of childhood obesity is increasing worldwide, along with the associated
common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated …

LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity

T Christova, SKY Ho, Y Liu, M Gill, L Attisano - EMBO reports, 2023 - embopress.org
The establishment of axon‐dendrite polarity is fundamental for radial migration of neurons,
cortical patterning, and formation of neuronal circuits. Here, we show that the receptor …

[HTML][HTML] Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells

NS Abdullah, A Bradaia, M Defaye, C Ohland… - Mucosal …, 2024 - Elsevier
Recent evidence suggests that the gut microbiota can influence pain sensitivity, highlighting
the potential for microbiota-targeted pain interventions. During early life, both the microbiota …

[HTML][HTML] Cytokines reprogram airway sensory neurons in asthma

T Crosson, S Bhat, JC Wang, C Salaun, E Fontaine… - Cell Reports, 2024 - cell.com
Nociceptor neurons play a crucial role in maintaining the body's homeostasis by detecting
and responding to potential environmental dangers. However, this function can be …

[PDF][PDF] Cytokines reprogram airway sensory neurons in asthma

T Crosson, S Bhat, JC Wang, C Salaun, E Fontaine… - BioRxiv, 2023 - academia.edu
IL-13 promotes sensory-sympathetic neurons crosstalk in asthma Théo Crosson 1,2, Shreyas
Bhat 2,3, Jo-Chiao Wang 1,2, Clara Sal Page 1 IL-13 promotes sensory-sympathetic neurons …

[HTML][HTML] A nociceptive amygdala-striatal pathway for chronic pain aversion

JA Wojick, A Paranjapye, JK Chiu, M Mahmood… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The basolateral amygdala (BLA) is essential for assigning positive or negative valence to
sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of nociceptive …