Over the past few decades, RNA sequencing has significantly progressed, becoming a
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …

Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that
regulate a wide variety of cellular processes, including proliferation, differentiation …

Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes,
and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is …

Methods We evaluated a comprehensive set of transcriptomic data sets to investigate the
associations of smoking with ACE2, FURIN, and TMPRSS2 gene expression in lung tissues …

The proto-oncogene ROS1 encodes a receptor tyrosine kinase with an unknown
physiological role in humans. Somatic chromosomal fusions involving ROS1 produce …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

In current severe global emergency situation of 2019-nCov outbreak, it is imperative to
identify vulnerable and susceptible groups for effective protection and care. Recently …

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report
molecular profiling of 230 resected lung adenocarcinomas using messenger RNA …

FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …