This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in
cataract formation and evaluates the potential of antioxidant therapies in mitigating this …

Choline is essential for maintaining the structure and function of cells in humans. Choline
plays an important role in eye health and disease. It is a precursor of acetylcholine, a …

Several discoveries show that with age and cataract formation, β-crystallin binds with the
lens membrane or associates with other lens proteins, which bind with the fiber cell plasma …

α-crystallin is a major protein found in the mammalian eye lens that works as a molecular
chaperone by preventing the aggregation of proteins and providing tolerance to stress in the …

Purpose This research aims to probe the interaction of α-crystallin with a model of human,
porcine, and mouse lens-lipid membranes. Methods Cholesterol/model of human lens-lipid …

The eye lens is a transparent, ellipsoid tissue in the anterior chamber that is required for the
fine focusing of light onto the retina to transmit a clear image. The focusing function of the …

Experimental evidence shows that the eye lens loses its elasticity dramatically with age. It
has also been reported that the cholesterol (Chol) content in the eye lens fiber cell plasma …

Several studies reported that α-crystallin concentrations in the eye lens cytoplasm decrease
with a corresponding increase in membrane-bound α-crystallin with age and cataracts. The …

The concentration of α-crystallin decreases in the eye lens cytoplasm, with a corresponding
increase in membrane-bound α-crystallin during cataract formation. The eye lens's fiber cell …

α-crystallin-membrane association increases with age and cataracts, with the primary
association site of α-crystallin being phospholipids. However, it is unclear if phospholipids' …