The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The background knowledge leading to the isolation and identification of anandamide and 2-
arachidonoyl glycerol, the principal endocannabinoids is described. The structure–activity …

The endogenous cannabinoid receptor agonist anandamide is a powerful vasodilator of
isolated vascular preparations,,, but its mechanism of action is unclear. Here we show that …

N-arachidonoylethanolamine (anandamide) was the first endogenous cannabinoid receptor
ligand to be discovered. Dual synthetic pathways for anandamide have been proposed. One …

The CB1 subtype of the cannabinoid receptor is present on neurons in the brain and
mediates the perceptual effects of Δ9-tetrahydrocannabinol and other cannabinoids. We …

Macrophages are the primary cellular targets of bacterial lipopolysaccharide (LPS), but the
role of macrophage‐derived cytokines in LPS‐induced septic shock is uncertain. Recent …

The only endogenous substances isolated and characterised so far that are capable of
mimicking the pharmacological actions of the active principle of marijuana,(−)-Δ9 …

The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is
controversial, putatively involving diffusible factors and/or electrotonic spread of …

Anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol mediate many of their
actions via either CB1 or CB2 cannabinoid receptor subtypes. These agonist-receptor …

2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated
from rat brain and canine gut as an endogenous cannabinoid receptor ligand (Sugiura, T …