Sexual dimorphism in chronic respiratory diseases

KD Reddy, BGG Oliver - Cell & Bioscience, 2023 - Springer
Sex differences in susceptibility, severity, and progression are prevalent for various diseases
in multiple organ systems. This phenomenon is particularly apparent in respiratory diseases …

Sex differences in airway disease: estrogen and airway surface liquid dynamics

BJ Harvey, NG McElvaney - Biology of sex Differences, 2024 - Springer
Biological sex differences exist for many airway diseases in which females have either
worse or better health outcomes. Inflammatory airway diseases such as cystic fibrosis (CF) …

The changing landscape of the cystic fibrosis lung environment: from the perspective of Pseudomonas aeruginosa

MA Greenwald, MC Wolfgang - Current Opinion in Pharmacology, 2022 - Elsevier
This review guides the reader through the current understanding of the dynamic changes
that occur within the cystic fibrosis (CF) lung that allow Pseudomonas aeruginosa to become …

[HTML][HTML] Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe

A Jung, A Orenti, F Dunlevy, E Aleksejeva… - ERJ open …, 2021 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
people with cystic fibrosis (pwCF) can lead to severe outcomes. Methods In this …

Cystic Fibrosis and Cancer: Unraveling the Complex Role of CFTR Gene in Cancer Susceptibility

GF Parisi, M Papale, G Pecora, N Rotolo, S Manti… - Cancers, 2023 - mdpi.com
Simple Summary Cystic fibrosis (CF) is a genetic condition that affects the lungs, digestion,
and other body systems. People with CF have a higher chance of developing certain types …

The gut-lung axis in the CFTR modulator era

F Lussac-Sorton, É Charpentier, S Imbert… - Frontiers in Cellular …, 2023 - frontiersin.org
The advent of CFTR modulators represents a turning point in the history of cystic fibrosis
(CF) management, changing profoundly the disease's clinical course by improving mucosal …

Sex differences in outcomes of people with cystic fibrosis treated with elexacaftor/tezacaftor/ivacaftor

A Wang, MJ Lee, A Keller, S Jian, K Lowe… - Journal of Cystic …, 2024 - Elsevier
Background There is a well described sex-disparity in outcomes of individuals with cystic
fibrosis (CF), with females faring worse than males. Given the dramatic improvement in …

Changes of androgen and corticosterone metabolites excretion and conversion in cystic fibrosis

R Podgórski, M Sumińska, M Rachel… - Frontiers in …, 2023 - frontiersin.org
Cystic fibrosis (CF) is a life-threatening inherited disease related to a mutation in the CFTR
gene, that leads to serious health complications such as chronic pulmonary infections …

Optimizing sexual and reproductive health across the lifespan in people with cystic fibrosis

NE West, TM Kazmerski, JL Taylor‐Cousar… - Pediatric …, 2022 - Wiley Online Library
With improved therapies, people with cystic fibrosis are living longer and healthier lives and
increasingly have questions surrounding their sexual and reproductive health. This article …

CF patients' airway epithelium and sex contribute to biosynthesis defects of pro-resolving lipids

M Shum, CM London, M Briottet, KA Sy… - Frontiers in …, 2022 - frontiersin.org
Specialized pro-resolving lipid mediators (SPMs) as lipoxins (LX), resolvins (Rv), protectins
(PD) and maresins (MaR) promote the resolution of inflammation. We and others previously …