Statin toxicity: mechanistic insights and clinical implications

NC Ward, GF Watts, RH Eckel - Circulation research, 2019 - Am Heart Assoc
There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …

Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications

M Ruscica, N Ferri, M Banach, CR Sirtori… - Cardiovascular …, 2022 - academic.oup.com
Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

Understanding the molecular mechanisms of statin pleiotropic effects

CA German, JK Liao - Archives of Toxicology, 2023 - Springer
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …

Statin-related myotoxicity: a comprehensive review of pharmacokinetic, pharmacogenomic and muscle components

RM Turner, M Pirmohamed - Journal of clinical medicine, 2019 - mdpi.com
Statins are a cornerstone in the pharmacological prevention of cardiovascular disease.
Although generally well tolerated, a small subset of patients experience statin-related …

The role of pharmacogenomics in adverse drug reactions

R Cacabelos, N Cacabelos, JC Carril - Expert Review of Clinical …, 2019 - Taylor & Francis
ABSTRACT Introduction: Adverse drug reactions (ADRs) are a major health concern
worldwide. There are multiple causes of ADRs, some of which are preventable …

Multi‐pathway microenvironment regulation for atherosclerosis therapy based on beta‐cyclodextrin/l‐arginine/Au nanomotors with dual‐mode propulsion

Z Wu, R Wu, X Li, X Wang, X Tang, K Tan, M Wan… - Small, 2022 - Wiley Online Library
Most of the current non‐pharmacological treatment strategies for atherosclerosis (AS) suffer
from poor penetration into the plaque and only aim at a certain factor in its formation …

Interface allocation precisely customized janus upconversion nanomotor for atherosclerosis amelioration

Y Zhang, C Liao, M Abudusaimaiti… - Advanced Functional …, 2024 - Wiley Online Library
Spatial and temporal precisely control of direction and speed is crucial for nanomotors to
enable complex operations and applications in microsurgery, drug delivery, isolation of …

Pharmacogenetics of statin-induced myotoxicity

PS Kee, PKL Chin, MA Kennedy, SDS Maggo - Frontiers in Genetics, 2020 - frontiersin.org
Statins, a class of lipid-lowering medications, have been a keystone treatment in
cardiovascular health. However, adverse effects associated with statin use impact patient …

Pharmacogenomics for primary care: an overview

V Rollinson, R Turner, M Pirmohamed - Genes, 2020 - mdpi.com
Most of the prescribing and dispensing of medicines happens in primary care.
Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation …

Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence

LR Brunham, S Baker, A Mammen… - Cardiovascular …, 2018 - academic.oup.com
Statin therapy reduces cardiovascular events in patients with, or at risk of, atherosclerotic
cardiovascular disease. However, statins are underutilized in patients for whom they are …