There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

Pattern separation and pattern completion processes are central to how the brain processes
information in an efficient manner. Research into these processes is escalating and deficient …

The hippocampal dentate gyrus is often viewed as a segregator of upstream information.
Physiological support for such function has been hampered by a lack of well-defined …

Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory
function by decorrelating overlapping input patterns (pattern separation). A second …

To determine how hippocampal backprojections influence spatially periodic firing in grid
cells, we recorded neural activity in the medial entorhinal cortex (MEC) of rats after …

CA1 cells receive direct input from space-responsive cells in medial entorhinal cortex
(MEC), such as grid cells, as well as more nonspatial cells in lateral entorhinal cortex (LEC) …

Grid cells are space-modulated neurons with periodic firing fields. In moving animals, the
multiple firing fields of an individual grid cell form a triangular pattern tiling the entire space …

The unitary firing fields of hippocampal place cells are commonly assumed to be generated
by input from entorhinal grid cell modules with differing spatial scales. Here, we review …

The hippocampus generates distinct neural codes to disambiguate similar experiences, a
process thought to underlie episodic memory function. Entorhinal grid cells provide a …

We develop further here the only quantitative theory of the storage of information in the
hippocampal episodic memory system and its recall back to the neocortex. The theory is …