Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+
influx in non-excitable and excitable (ie, skeletal and cardiac muscle) cells. These channels …

Atrial fibrillation (AF) is the most common arrhythmia and is associated with inflammation. AF
patients have elevated levels of inflammatory cytokines known to promote vascular leak …

During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different
scales from the molecular level to the tissue level. One central player that contributes to both …

Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin
secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum …

Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse
cellular functions including cell survival, metabolism, and transcription. As a result …

Abstract Store‐operated Ca2+ entry (SOCE) machinery, including Orai channels, TRPCs,
and STIM1, is key to cellular calcium homeostasis. The following characteristics of …

Inositol 1, 4, 5-trisphosphate receptors (IP3Rs) play a crucial role in maintaining
intracellular/cytosolic calcium ion (Ca2+ i) homeostasis. The release of Ca2+ from IP3Rs …

Right ventricular failure (RVF) is the most important prognostic factor for morbidity and
mortality in pulmonary arterial hypertension (PAH) or pulmonary hypertension (PH) caused …

Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-
economic burden. Calcium (Ca2+) dysregulation is key hallmark of the failing myocardium …