Significant evidence suggests that reversible oxidation of methionine residues provides a
mechanism capable of scavenging reactive species, thus creating a cycle with catalytic …

Factor XIII-A (FXIII-A) deficiency is an ultra-rare bleeding disorder characterized by high
rates of morbidity and mortality, primarily resulting from intracranial hemorrhage, umbilical …

Coagulation factor XIII (FXIII) acts as a fine fulcrum in blood plasma that maintains the
balance between bleeding and thrombosis by covalently crosslinking the pre-formed fibrin …

The structure of human coagulation factor XIII (FXIII), a heterotetrameric plasma
protransglutaminase that covalently cross-links preformed fibrin polymers, remains elusive …

Transglutaminase factor XIII (FXIII) is essential for hemostasis, wound healing, and
pregnancy maintenance. Plasma FXIII is composed of A and B subunit dimers synthesized …

Coagulation factor XIII (FXIII) circulates in plasma as a pro-transglutaminase
heterotetrameric complex (FXIIIA2B2), which upon activation by thrombin and calcium …

The blood coagulation factor XIII (FXIII) plays a critical role in supporting coagulation and
fibrinolysis due to both the covalent crosslinking of fibrin polymers, rendering them resistant …

Abstract Background Acquired hemophilia A (AHA) is a rare and severe bleeding disorder
characterized by autoantibodies inhibiting coagulation factor (F) VIII. Current treatment of …

Background The characterization of inherited mild factor XIII deficiency is more imprecise
than its rare, inherited severe forms. It is known that heterozygosity at FXIII genetic loci …

Coagulation factor XIII (FXIII) is a protransglutaminase which plays an important role in clot
stabilization and composition by cross-linking the α-and γ-chains of fibrin and increasing the …