BACKGROUND When considering whether a patient is fit for surgery, a comprehensive
patient assessment represents the first step for an anaesthetist to evaluate the risks …

Guidelines Management of severe peri-operative bleeding: Guidelines from the European
Society of Anaesthesiology and Intensive Care

Clinical guidelines and expert groups recommend the use of pharmacokinetic (PK)-guided
dosing of factor replacement therapy for the treatment of bleeding disorders, especially for …

Nonlinear mixed effect (NLME) models are the gold standard for the analysis of patient
response following drug exposure. However, these types of models are complex and time …

Background Treatment choices for individual patients with an inborn bleeding disorder are
increasingly challenging due to increasing options and rising costs for society. We have …

Introduction Non‐severe haemophilia A patient can be treated with desmopressin or factor
VIII (FVIII) concentrate. Combining both may reduce factor consumption, but its feasibility …

In rare diseases, such as hemophilia A, the development of accurate population
pharmacokinetic (PK) models is often hindered by the limited availability of data. Most PK …

In resource-rich countries, almost all severe hemophilia patients receive prophylactic
replacement therapy with factor concentrates to prevent spontaneous bleeding in joints and …

Conventional pharmacokinetic (PK) models contain several useful inductive biases guiding
model convergence to more realistic predictions of drug concentrations. Implementing …

This work focusses on extending the deep compartment model (DCM) framework to the
estimation of mixed-effects. By introducing random effects, model predictions can be …