Defects of mitochondrial metabolism cause a wide range of human diseases that include
examples from all medical subspecialties. This review updates the topic of mitochondrial …

The biological activity of steroid hormones is regulated at the pre-receptor level by several
enzymes including 17 beta-hydroxysteroid dehydrogenases (17 beta-HSD). The latter are …

Mitochondrial dysfunction is a hallmark of β-amyloid (Aβ)–induced neuronal toxicity in
Alzheimer's disease (AD). Here, we demonstrate that Aβ-binding alcohol dehydrogenase …

Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Abnormalities in
mitochondrial properties include impaired energy metabolism, defects in key respiratory …

Amyloid‐β peptide (Aβ) binding alcohol dehydrogenase (ABAD), an enzyme present in
neuronal mitochondria, is a cofactor facilitating Aβ‐induced cell stress. We hypothesized that …

The progress in genome characterizations has opened new routes for studying enzyme
families. The availability of the human genome enabled us to delineate the large family of …

Rapidly proliferating cells such as cancer cells and embryonic stem cells rely on a
specialized metabolic program known as aerobic glycolysis, which supports biomass …

Human brain short chainl-3-hydroxyacyl-CoA dehydrogenase (SCHAD) was found to
catalyze the oxidation of 17β-estradiol and dihydroandrosterone as well as alcohols …

An important means of determining how amyloid‐beta peptide (Aβ) affects cells is to identify
specific macromolecular targets and assess how Aβ interaction with such targets impacts on …

Remarkable advances have been made in recent years in our understanding of the
Drosophila fat body and its functions in energy storage, immune response and nutrient …