Platelets are the smallest blood cells, numbering 150 to 350× 10 9/L in healthy individuals.
The ability of activated platelets to adhere to an injured vessel wall and form aggregates was …

The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a
major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in …

Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von
Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and …

Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …

Platelet activation is a complex balance of positive and negative signaling pathways. The
protein kinase C (PKC) family is a major regulator of platelet granule secretion, integrin …

The importance of the second messengers calcium (Ca2+) and diacylglycerol (DAG) in
platelet signal transduction was established more than 30 years ago. Whereas protein …

Abstract Thrombospondin-1 (TSP-1) is released by platelets upon activation and can
increase platelet activation, but its role in hemostasis in vivo is unclear. We show that TSP-1 …

BACKGROUND: MAGT1 (magnesium transporter 1) is a subunit of the oligosaccharide
protein complex with thiol-disulfide oxidoreductase activity, supporting the process of N …

Arterial thrombosis, a major cause of myocardial infarction and stroke, is initiated by
activation of blood platelets by subendothelial collagen. The protein kinase C (PKC) family …

Integrin αIIbβ3 activation is essential for platelet aggregation and, accordingly, for
hemostasis and arterial thrombosis. The αIIbβ3 integrin is highly expressed on platelets and …