Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …
the offspring. The maternal immune activation hypothesis proposes that inflammatory …
[HTML][HTML] Effects of prenatal hypoxia on nervous system development and related diseases
B Wang, H Zeng, J Liu, M Sun - Frontiers in neuroscience, 2021 - frontiersin.org
The fetal origins of adult disease (FOAD) hypothesis, which was proposed by David Barker
in the United Kingdom in the late 1980s, posited that adult chronic diseases originated from …
in the United Kingdom in the late 1980s, posited that adult chronic diseases originated from …
Prenatal exposure to maternal social disadvantage and psychosocial stress and neonatal white matter connectivity at birth
Early life adversity (social disadvantage and psychosocial stressors) is associated with
altered microstructure in fronto-limbic pathways important for socioemotional development …
altered microstructure in fronto-limbic pathways important for socioemotional development …
[HTML][HTML] Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction
BA Bakrania, FT Spradley, HA Drummond… - Comprehensive …, 2020 - ncbi.nlm.nih.gov
Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …
United States and affects over 200,000 women and newborns per year. The United States …
Pre‐eclampsia and long‐term health outcomes for mother and infant: An umbrella review
T Pittara, A Vyrides, D Lamnisos… - BJOG: An International …, 2021 - Wiley Online Library
Background Pre‐eclampsia is a pregnancy‐associated condition with complex disease
mechanisms and a risk factor for various long‐term health outcomes for the mother and …
mechanisms and a risk factor for various long‐term health outcomes for the mother and …
[HTML][HTML] Maternal autoimmunity and inflammation are associated with childhood tics and obsessive-compulsive disorder: transcriptomic data show common enriched …
Although genetic variation is a major risk factor of neurodevelopmental disorders,
environmental factors during pregnancy and early life are also important in disease …
environmental factors during pregnancy and early life are also important in disease …
The serotonin-immune axis in preeclampsia
Abstract Purpose of Review To review the literature and detail the potential immune
mechanisms by which hyperserotonemia may drive pro-inflammation in preeclampsia and to …
mechanisms by which hyperserotonemia may drive pro-inflammation in preeclampsia and to …
[HTML][HTML] The role of nutrients in human neurodevelopment and their potential to prevent neurodevelopmental adversity
Nutritional deficits or excesses affect a huge proportion of pregnant women worldwide.
Maternal nutrition has a significant influence on the fetal environment and can dramatically …
Maternal nutrition has a significant influence on the fetal environment and can dramatically …
[HTML][HTML] Placental dysfunction: the core mechanism for poor neurodevelopmental outcomes in the offspring of preeclampsia pregnancies
D Liu, Q Gao, Y Wang, T Xiong - Placenta, 2022 - Elsevier
Preeclampsia (PE) is a leading condition threatening pregnant women and their offspring.
The offspring of PE pregnancies have a high risk of poor neurodevelopmental outcomes and …
The offspring of PE pregnancies have a high risk of poor neurodevelopmental outcomes and …
Circulating maternal sFLT1 (soluble fms-like tyrosine kinase-1) is sufficient to impair spiral arterial remodeling in a preeclampsia mouse model
R Vogtmann, J Heupel, F Herse, M Matin… - …, 2021 - Am Heart Assoc
One driving factor for developing preeclampsia—a pregnancy disorder, often associated
with poor spiral artery (SpA)-remodeling and fetal growth restriction—is the anti-angiogenic …
with poor spiral artery (SpA)-remodeling and fetal growth restriction—is the anti-angiogenic …