Iron chelators in treatment of iron overload

S Entezari, SM Haghi, N Norouzkhani… - Journal of …, 2022 - Wiley Online Library
Patients suffering from iron overload can experience serious complications. In such patients,
various organs, such as endocrine glands and liver, can be damaged. Although iron is a …

A systematic review of adherence to iron chelation therapy among children and adolescents with thalassemia

PS Reddy, M Locke, SM Badawy - Annals of Medicine, 2022 - Taylor & Francis
Introduction Iron chelation therapy (ICT) is essential to prevent complications of iron
overload in patients with transfusion-dependent thalassaemia. However, there is currently …

[HTML][HTML] Therapeutic potential of induced iron depletion using iron chelators in Covid-19

PP Naseef, M Elayadeth-Meethal, KTM Salim… - Saudi Journal of …, 2022 - Elsevier
Ferritin, which includes twenty-four light and heavy chains in varying proportions in different
tissues, is primarily responsible for maintaining the body's iron metabolism. Its normal value …

An insight into Indonesian current thalassaemia care and challenges

PA Wahidiyat, TT Sari, LD Rahmartani… - ISBT Science …, 2020 - Wiley Online Library
Thalassaemia is one of the most prevalent inherited blood disorders in Indonesia, with
highly diverse mutations ranging from mild to severe that can be found across the nation …

Adherence to iron chelation therapy among adults with thalassemia: a systematic review

M Locke, PS Reddy, SM Badawy - Hemoglobin, 2022 - Taylor & Francis
Iron chelation therapy (ICT) is essential to prevent complications of iron overload in patients
with transfusion-dependent thalassemia. However, the role that adherence to ICT plays in …

[HTML][HTML] Glucose Homeostasis and Assessment of β-Cell Function by 3-hour Oral Glucose Tolerance (OGTT) in Patients with β-Thalassemia Major with Serum Ferritin …

V De Sanctis, AT Soliman, S Daar… - … of Hematology and …, 2023 - ncbi.nlm.nih.gov
Aims The primary aim of this study was to evaluate retrospectively the glucose homeostasis
and surrogate indices of insulin sensitivity and resistance, during a 3-hour oral glucose …

Cardiomyopathy in thalassemia: quick review from cellular aspects to diagnosis and current treatments

M Ghanavat, H Haybar, SMS Pezeshki… - Laboratory …, 2020 - academic.oup.com
Background Cardiomyopathic manifestations induced by continuous blood transfusion are
the leading cause of death among patients with thalassemia major (TM). Despite …

Beta‐Thalassemia Major and Myocardial Iron Overload: A Longitudinal Study with Magnetic Resonance Imaging

K Rezaei-Kalantari, E Meftah, S Tofighi… - Cardiology …, 2024 - Wiley Online Library
Background. Patients with β‐thalassemia major depend on lifelong transfusion, resulting in
tissue iron overload. This longitudinal retrospective observational study aims to assess …

Comparison of Magnetic Resonance Imaging T2 Results in Beta-Thalassemia Patients Treated by Deferasirox or Combination of Deferoxamine and Deferiprone

N Mirbehbahani, G Vaseghi… - Iranian Journal of …, 2020 - publish.kne-publishing.com
Background: Iron extra load is an anticipated and lethal consequence of chronic blood
transfusion in major beta-thalassemia patients; therefore it is necessary to use an efficient …

The Effect of Combination Iron Chelating Agents on Reducing the Severity Grading of Heart and Liver Iron Overload in β-Thalassemia Patients

M Ghanavat, N Reisi - Iranian Journal of Pediatric Hematology and …, 2019 - ijpho.ssu.ac.ir
Background: Deferasirox (DFX), Deferoxamine (DFO), and Deferiprone (DFP) are iron
chelators that can be used in thalassemic patients with iron overload. Materials and …