Adult humans fail to regenerate their hearts following injury, and this failure to regenerate
myocardium is a leading cause of heart failure and death worldwide. Although all adult …

Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally
in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a …

Heart regeneration is limited in adult mammals but occurs naturally in adult zebrafish
through the activation of cardiomyocyte division. Several components of the cardiac injury …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

Cardiovascular disease is the leading cause of death worldwide. Compared to other organs
such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic …

In contrast to mammals, zebrafish regenerate heart injuries via proliferation of
cardiomyocytes located near the wound border. To identify regulators of cardiomyocyte …

Unlike adult mammals, adult zebrafish vigorously regenerate lost heart muscle in response
to injury. The epicardium, a mesothelial cell layer enveloping the myocardium, is activated to …

Defective coronary network function and insufficient blood supply are both cause and
consequence of myocardial infarction. Efficient revascularization after infarction is essential …