Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Cancer is considered the most important clinical, social and economic issue regarding
cause‑specific disability‑adjusted life years among all human pathologies. Exogenous …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Emerging evidence has shown that leukocyte telomere length (LTL) is associated with
various health‐related outcomes, while the causality of these associations remains unclear …

Pancreatic cancer (PC), particularly its most common form, pancreatic ductal
adenocarcinoma (PDAC), is relatively rare but highly lethal. Knowledge about PC risk …

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of
risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of …

Background Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in
early stages, and the disease is typically diagnosed in advanced phases, resulting in very …

Over the past decade, telomeres have attracted increasing attention due to the role they play
in human fertility. However, conflicting results have been reported on the possible …

In the last decades the association of leukocyte telomere length (LTL) and mitochondrial
copy number (mtDNAcn) with cancer risk has been the focus of many reports, however the …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality,
which threats peoples' health. Unfortunately, the pathogenesis of PDAC remains unclear …