Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …

Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …

Ovarian cancer and triple-negative breast cancer are among the most lethal diseases
affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are …

Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-
ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Breast cancer is a complex disease which is found as the second cause of cancer‐
associated death among women. Accumulating of evidence indicated that various factors …

Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis,
heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a …

Tumor-initiating cells (T-ICs) are a subpopulation of chemoresistant tumor cells that have
been shown to cause tumor recurrence upon chemotherapy. Identification of T-ICs and their …

Finding effective treatments for cancer remains a challenge. Recent studies have found that
the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal …

Cells with distinct phenotypes including stem-cell-like properties have been proposed to
exist in normal human mammary epithelium and breast carcinomas, but their detailed …