Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

The demand for modified peptides with improved stability profiles and pharmacokinetic
properties is driving extensive research effort in this field. Many structural modifications of …

Protein-protein interactions (PPIs) are fundamental to cellular signaling and transduction
which marks them as attractive therapeutic drug development targets. What were once …

The shortcomings of native peptides as pharmaceuticals have been long known: short
duration of action, lack of receptor selectivity, lack of oral bioavailability. However medicinal …

Non-proteinogenic prolines have been acknowledged as an important pool for the synthesis
of conformationally rigid bioactive peptides, angiotensin converting enzyme inhibitors and …

Anodic olefin coupling reactions using a tosylamine trapping group have been studied. The
cyclizations are favored by the use of a less-polar radical cation and more basic reaction …

The N-methylation of cyclic peptides can be used to modify the activity and/or selectivity of
biologically active peptides. As N-methylation introduces different flexibility and lipophilicity …

The prostaglandin F2α (PGF2α) receptor (FP) is a key regulator of parturition and a target for
pharmacological management of preterm labor. However, an incomplete understanding of …

In a time of emerging bacterial resistance there is a vital need for new targets and strategies
in antibacterial therapy. Using uropathogenic Escherichia coli as a model pathogen we have …