The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …

The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …

IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK
cells, and macrophages, all of which are required for optimal pathogen clearance but also …

Research on the biological function of nuclear factor-κB (NF-κB), a key mediator of inducible
transcription in the immune system, has traditionally focused on its role in the initiation of …

Mucosal surfaces such as the intestinal tract are continuously exposed to both potential
pathogens and beneficial commensal microorganisms. This creates a requirement for a …

Dendritic cells (DCs) produce cytokines and are susceptible to cytokine-mediated activation.
Thus, interaction of resting immature DCs with TLR ligands, for example nucleic acids, or …

Neurodegenerative diseases are a growing health concern. The increasing incidences of
these disorders have a great impact on the patients' quality of life. Although the mechanisms …

Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-
inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to …

Objective: In mice, a subpopulation of gut dendritic cells (DCs) expressing CD103 drives the
development of regulatory T (Treg) cells. Further, it was recently described that the cross-talk …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …