Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Drug resistance develops in nearly all patients with colon cancer, leading to a decrease in
the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Mutations in cancer cells frequently result in cell cycle alterations that lead to unrestricted
growth compared to normal cells. Considering this phenomenon, many drugs have been …

Multidrug resistance‐associated protein 1 (MRP1, ABCC1) is an ATP‐binding cassette
(ABC) transport protein. This efflux pump uses the energy of ATP hydrolysis to export …

Pharmacologic inhibition of the oncogenic protein kinases using small molecules is a
promising strategy to combat several human malignancies. CDK1 is an example of such a …

Ribociclib is a novel cyclin-dependent kinase (CDK) 4 and 6 selective inhibitor that recently
gained breakthrough therapy status and global approval for advanced breast cancer …

Purpose Doxorubicin is one of the most active agents in the first-line therapy for metastatic
breast cancer, but its utility is partially limited by the frequent emergence of doxorubicin …

A virtual screening protocol with combination of similarity search and pharmacophore
modeling was applied to virtually screen a large compound library to gain new scaffolds …

Methyl mercury (MeHg) is an organic highly toxic compound that is transported efficiently via
the human placenta. Our previous data suggest that MeHg is taken up into placental cells by …