Exosome, a subpopulation of extracellular vesicles, plays diverse roles in various biological
processes. As one of the most abundant components of exosomes, exosomal proteins have …

Ovarian cancer (OVCA) is the second most common gynecological cancer and one of the
leading causes of cancer related mortality among women. Recent studies suggest that …

Ovarian cancer (OVCA) is the most lethal gynecological cancer, due predominantly to late
presentation, high recurrence rate and common chemoresistance development. The …

Background Obstructive sleep apnea is associated with increased lung cancer incidence
and mortality. Cancer stem cells (CSCs) are characterized by their self-renewing ability …

Hypoxia, a common factor ruling the microenvironment composition, leads to tumor
progression. In this hypoxic context, cytokines and cells cooperate to favor cancer …

Once thought to be exclusively a storage hub for glucose, glycogen is now known to be
essential in a range of physiological processes and pathological conditions. Glycogen lies at …

Pancreatic cancer is the third leading cause of cancer death in the USA, and pancreatic
ductal adenocarcinoma (PDA) constitutes 85% of pancreatic cancer diagnoses. PDA …

Rab GTPases are important regulators of intracellular membrane trafficking in eukaryotes.
Both activating and inactivating mutations in Rab genes have been identified and implicated …

Rab25, a small GTPase belongs to the Rab protein family, has a pivotal role in cancer
pathophysiology. Rab25 governs cell-surface receptors recycling and cellular signaling …

Migration and invasion inhibitory protein (MIIP) is recently identified as an inhibitor in tumor
development. However, the regulatory mechanism and biological contributions of MIIP in …