Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Cell transplantation therapies have become a major focus in pre-clinical research as a
promising strategy for the treatment of spinal cord injury (SCI). In this article, we …

Astrocytes can be generated from various tissue sources including human pluripotent stem
cells (PSC). In this manuscript, we describe a chemically defined xeno-free medium culture …

The diverse functions of glial cells prompt the question to which extent specific subtypes may
be devoted to a specific function. We discuss this by reviewing one of the most recently …

Transplantation of neural progenitor cells (NPC) is a promising therapeutic strategy for
replacing neurons lost after spinal cord injury, but significant challenges remain regarding …

Spinal cord injury (SCI), resulting in para-and tetraplegia caused by the partial or complete
disruption of descending motor and ascending sensory neurons, represents a complex …

Background Traumatic spinal cord injury (SCI) results in partial or complete paralysis and is
characterized by a loss of neurons and oligodendrocytes, axonal injury, and demyelination …

Demyelination contributes to the physiological and behavioral deficits after contusive spinal
cord injury (SCI). Therefore, remyelination may be an important strategy to facilitate repair …

Neurons and oligodendrocytes are highly vulnerable to various insults, and their
spontaneous replacement occurs to only a limited extent after damage in the adult spinal …