Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as
antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton …

INTRODUCTION The four-component Ugi reaction (Ugi-4CR) assembles peptide-like α-
acylaminoamides through one-pot reaction of a carbonyl compound, an amine, an acid, and …

Abstract The Drug Design Data Resource (D3R) ran Grand Challenge 2 (GC2) from
September 2016 through February 2017. This challenge was based on a dataset of …

Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies
and applications for multicomponent reactions–including key routes for synthesizing …

FXR agonists have demonstrated very promising clinical results in the treatment of liver
disorders such as primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and …

Fibroblast growth factor 19 (FGF19) is proposed to be a negative feedback regulator of
hepatic bile acid (BA) synthesis. We aimed to clarify the distribution of FGF19 expression in …

Bile acids are steroid-derived molecules synthesized in the liver, secreted from hepatocytes
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …

1, 3-Dimethyl-2-arylbenzimidazole (DMBI) derivatives act as good electron dopants for
semiconductors and form DMBI cations (DMBI+). However, in the presence of oxygen …

Isocyanides were formally discovered by Gautier1 and Hofmann2 in 1867 but the history of
isocyanide chemistry in fact predates this discovery. Lieke carried out the first isocyanide …