In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Membrane proteins mediate many critical functions in cells. Determining their three-
dimensional structures in the native lipid environment has been one of the main objectives …

Conspectus Membrane proteins mediate a plethora of cellular functions and represent
important targets for drug development. Unlike soluble proteins, membrane proteins require …

Multiplexing NMR experiments by direct detection of multiple free induction decays (FIDs) in
a single experiment offers a dramatic increase in the spectral information content and often …

It has been slightly more than fifty years since the first homonuclear spin decoupling
scheme, Lee-Goldburg decoupling, was proposed for removing homonuclear dipolar …

The sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) plays a central role in muscle
contractility and nonshivering thermogenesis. SERCA is regulated by sarcolipin (SLN), a …

Obtaining site-specific assignments for the NMR spectra of proteins in the solid state is a
significant bottleneck in deciphering their biophysics. This is primarily due to the time …

SERCA is a P-type ATPase embedded in the sarcoplasmic reticulum and plays a central
role in muscle relaxation. SERCA's function is regulated by single-pass membrane proteins …

High-ordered multiple-quantum coherences have been used to gauge the size of coupled
networks of nuclear spins but are seldom used in modern high-resolution solid-state NMR …

Oriented solid-state NMR (O-ssNMR) spectroscopy is a major technique for the high-
resolution analysis of the structure and topology of transmembrane proteins in native-like …