Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which
is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

The gut microbiota is a key environmental determinant of mammalian metabolism.
Regulation of white adipose tissue (WAT) by the gut microbiota is a process critical to …

Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …

Abstract MicroRNAs (miRNAs), small non-coding RNAs, can regulate post-transcriptional
gene expressions and silence a broad set of target genes. miRNAs, aberrantly expressed in …

Podocyte injury is a major determinant of proteinuric kidney disease and the identification of
potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we …