Intracellular Ca 2+ signals are temporally controlled and spatially restricted. Signaling
occurs adjacent to sites of Ca 2+ entry and/or release, where Ca 2+-dependent effectors and …

Centrioles are microtubule-based organelles responsible for forming centrosomes and cilia,
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …

Aim To place the consequences of calcineurin inhibition in a cardiovascular context.
Methods Literature review coupled with personal encounters. Results Calcineurin is a …

Centrosomes have critical roles in microtubule organization, ciliogenesis, and cell signaling.
1, 2, 3, 4, 5, 6, 7, 8 Centrosomal alterations also contribute to diseases, including …

Adaptation to external environmental challenges at the cellular level requires rapid
responses and involves relay of information to the nucleus to drive key gene expression …

The JCS Prize, of£ 1000, is awarded annually to the first author (s) of the paper that is
judged by the Editors and Editor-in-Chief to be the best research article published in Journal …

Calcineurin (CN), the only Ca2+-calmodulin activated protein phosphatase,
dephosphorylates substrates within membrane-associated Ca2+ microdomains. CN binds to …

Polycystins are conserved eukaryotic mechanosensitive ion channels. Loss-of-function
mutations in human polycystins lead to a common genetic disorder known as autosomal …

Calcineurin, a highly conserved Ca 2+ and calmodulin-activated phosphatase, has been
most extensively studied in the context of the adaptive immune response. Due to its role in …

First Person is a series of interviews with the first authors of a selection of papers published
in Journal of Cell Science, helping researchers promote themselves alongside their papers …