Cyclization is an important post-translational modification of peptides and proteins that
confers key advantages such as protection from proteolytic degradation, altered solubility …

All known organisms encode 20 canonical amino acids by base triplets in the genetic code.
The cellular translational machinery produces proteins consisting mainly of these amino …

Thrombosis is a leading cause of death worldwide. Recombinant tissue-type plasminogen
activator (tPA) is the Food and Drug Administration-approved thrombolytic drug. tPA is …

A peptide segment that binds the active site of a serine protease in a substrate-like manner
may behave like an inhibitor or a substrate. However, there is sparse information on which …

Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant
management in venous thrombosis. While efficacious, they are difficult to use due to …

Peptides have attracted much attention recently owing to their well-balanced properties as
drugs against protein–protein interaction (PPI) surfaces. Molecular simulation-based …

The urokinase plasminogen activator (uPA) is a widely studied anticancer drug target with
multiple classes of inhibitors reported to date. Many of these inhibitors contain amidine or …

Urokinase-type plasminogen activator (uPA) is a diagnostic marker for breast and prostate
cancers recommended by American Society for Clinical Oncology and German Breast …

All serine proteases hydrolyze peptide bonds by the same basic mechanism and have very
similar active sites, in spite of the fact that individual proteases have different physiological …

Because of the high similarity in structure and sequence, it is challenging to distinguish the
S1 pocket among serine proteases, primarily due to the only variability at residue 190 (A190 …