As the details of the chemical transformations in metabolism have become increasingly
clear, and the enzymes catalysing many of the reactions have been characterized, it is …

The literature on Control is distinguished by a vast quantity of detailed information on
particular systems and very little discussion on general problems. There also appears to be …

There is little doubt that the central areas of traditional biochemistry (such as metabolism,
metabolic regulation and enzymology) are currently unfashionable and generally regarded …

There is no doubt that nowadays, biology benefits greatly from mathematics. In particular,
cellular biology is, besides population dynamics, a field where tech niques of mathematical …

This article gives an overview of recent developments in the modelling of the structure,
control and optimality of metabolic networks. In particular, methods of algebraically …

Using a computer model of oxidative phosphorylation developed previously [Korzeniewski
and Mazat (1996) Biochem. J. 319, 143–148; Korzeniewski and Zoladz (2001) Biophys …

Metabolic channeling is the term used to describe the restricted flow of substrates and
products in multienzyme systems. It has been argued for some time that free diffusion is …

A methodology for characterizing metabolic systems using the response, control, and
elasticity coefficients has emerged since the early 1970s. This methodology, termed …

The three main existing models for glycolytic oscillations in yeast were re-examined to
investigate how these oscillations are controlled. We implemented the operational …

Various definitions of coefficients in metabolic control analysis are examined with respect to
their theoretical consistency and practical applicability. We suggest agreement upon a …