Induction of mucosal immunity through systemic immunization: Phantom or reality?
F Su, GB Patel, S Hu, W Chen - Human vaccines & …, 2016 - Taylor & Francis
Generation of protective immunity at mucosal surfaces can greatly assist the host defense
against pathogens which either cause disease at the mucosal epithelial barriers or enter the …
against pathogens which either cause disease at the mucosal epithelial barriers or enter the …
Human immunodeficiency virus vaccine trials
RJ O'Connell, JH Kim, L Corey… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
More than 2 million AIDS-related deaths occurred globally in 2008, and more than 33 million
people are living with HIV/AIDS. Despite promising advances in prevention, an estimated …
people are living with HIV/AIDS. Despite promising advances in prevention, an estimated …
Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques
A Valentin, C Bergamaschi, M Rosati, M Angel… - Frontiers in …, 2022 - frontiersin.org
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …
animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) …
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
Background None of the HIV T-cell vaccine candidates that have reached advanced clinical
testing have been able to induce protective T cell immunity. A major reason for these failures …
testing have been able to induce protective T cell immunity. A major reason for these failures …
Immunity against heterosubtypic influenza virus induced by adenovirus and MVA expressing nucleoprotein and matrix protein-1
T Lambe, JB Carey, Y Li, AJ Spencer… - Scientific reports, 2013 - nature.com
Alternate prime/boost vaccination regimens employing recombinant replication-deficient
adenovirus or MVA, expressing Influenza A virus nucleoprotein and matrix protein 1 …
adenovirus or MVA, expressing Influenza A virus nucleoprotein and matrix protein 1 …
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques
Intramuscular injection of macaques with an IL-12 expression plasmid (0.1 or 0.4 mg
DNA/animal) optimized for high level of expression and delivered using in vivo …
DNA/animal) optimized for high level of expression and delivered using in vivo …
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge
We have previously shown that macaques vaccinated with DNA vectors expressing
SIVmac239 antigens developed potent immune responses able to reduce viremia upon high …
SIVmac239 antigens developed potent immune responses able to reduce viremia upon high …
[HTML][HTML] HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques
J Li, A Valentin, V Kulkarni, M Rosati, RK Beach… - Vaccine, 2013 - Elsevier
Abstract Vaccination with HIV/SIV DNAs elicits potent T-cell responses. To improve humoral
immune responses, we combined DNA and protein in a co-immunization protocol using in …
immune responses, we combined DNA and protein in a co-immunization protocol using in …
Strategies for inducing effective neutralizing antibody responses against HIV-1
I del Moral-Sánchez, K Sliepen - Expert review of vaccines, 2019 - Taylor & Francis
Introduction: Despite intensive research efforts, there is still no effective prophylactic vaccine
available against HIV-1. Currently, substantial efforts are devoted to the development of …
available against HIV-1. Currently, substantial efforts are devoted to the development of …
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques
V Kulkarni, A Valentin, M Rosati, C Alicea, AK Singh… - PloS one, 2014 - journals.plos.org
HIV sequence diversity and potential decoy epitopes are hurdles in the development of an
effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24gag …
effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24gag …