Strategies for overcoming the biological barriers associated with the administration of inhaled monoclonal antibodies for lung diseases

MG Matera, L Calzetta, B Rinaldi… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Monoclonal antibodies (mAbs) should be administered by inhalation rather than
parenterally to improve their efficiency in lung diseases. However, the pulmonary …

Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial

B Maranda, SM Labbé, M Lurquin… - The Lancet Infectious …, 2024 - thelancet.com
Background COVID-19 severity is associated with its respiratory manifestations. Neutralising
antibodies against SARS-CoV-2 administered systemically have shown clinical efficacy …

Progress in novel delivery technologies to improve efficacy of therapeutic antibodies

W Sun, Y Wu, T Ying - Antiviral Research, 2024 - Elsevier
Monoclonal antibody-based therapeutics have achieved remarkable success in treating a
wide range of human diseases. However, conventional systemic delivery methods have …

Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation

HC Seow, JP Cai, HW Pan, C Luo, K Wen… - … Clinics and Research, 2023 - journals.lww.com
Neutralising monoclonal antibody (mAb) is an important weapon in our arsenal for
combating respiratory viral infections. However, the effectiveness of neutralising mAb has …

[HTML][HTML] Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe …

HW Pan, J Guo, L Zhu, SWS Leung, C Zhang… - International Journal of …, 2023 - Elsevier
The advent of biologics has brought renewed hope for patients with severe asthma, a
condition notorious for being hampered by poor response to conventional therapies and …

Exploring shark VNAR antibody against infectious diseases using phage display technology

HT Lim, BH Kok, CY Leow, CH Leow - Fish & Shellfish Immunology, 2023 - Elsevier
Antibody with high affinity and specificity to antigen has widely used as a tool to combat
various diseases. The variable domain of immunoglobulin new antigen receptor (VNAR) …

In vivo antiviral efficacy of LCTG-002, a pooled, purified human milk secretory IgA product, against SARS-CoV-2 in a murine model of COVID-19

V Mane, R Mehta, N Alvarez, V Sharma… - Human Vaccines & …, 2024 - Taylor & Francis
Immunoglobulin A (IgA) is the most abundant antibody (Ab) in human mucosae, with
secretory form (sIgA) being dominant and uniquely stable. sIgA is challenging to produce …

Antimicrobial Peptides and Proteins for Inhalation

Y Wang, RYK Chang, WJ Britton, HK Chan - Respiratory Delivery of …, 2024 - Springer
Antimicrobial peptides and proteins (APPs) are gaining attraction as powerful agents against
multidrug-resistant bacteria. The inhalation delivery of APPs has emerged as a potent tool …

Intranasal and Inhaled Vaccines

MYT Chow, JKW Lam - Respiratory Delivery of Biologics, Nucleic Acids …, 2024 - Springer
Many respiratory infections have epidemic and pandemic potential, as evidenced by
influenza and the recent COVID-19 pandemic. Vaccination is an established and effective …

Nanobodies as Spray and Aerosol Particles: A Breakthrough in Treating Respiratory Viral Infections

M Mustafa, A Mohammed - 2023 - preprints.org
Respiratory viral infections, including influenza, respiratory syncytial virus (RSV), and, more
recently, the coronavirus disease 2019 (COVID-19) pandemic, continue to pose significant …