Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

The field of artificial metalloenzymes (ArMs) is rapidly growing and ArMs are attracting
increasing attention, for example, in the fields of biosensing and drug therapy. Protein …

Late-stage functionalization of natural products offers an elegant route to create novel
entities in a relevant biological target space. In this context, enzymes capable of …

Considering the intrinsic toxicities of transition metals, their incorporation into drug therapies
must operate at minimal amounts while ensuring adequate catalytic activity within complex …

Enantioselective C–H amidation offers attractive means to assemble C–N bonds to
synthesize high-added value, nitrogen-containing molecules. In recent decades …

This review analyzes a development in biochemistry, enzymology and biotechnology that
originally came as a surprise. Following the establishment of directed evolution of …

Artificial metalloenzymes result from anchoring an organometallic catalyst within an
evolvable protein scaffold. Thanks to its dimer of dimers quaternary structure, streptavidin …

Synthetic biology aims at designing new biological functions from first principles. These new
designs allow to expand the natural solution space and overcome the limitations of naturally …

The development of artificial metalloenzymes (ArMs) aims to expand the capabilities of
enzymatic catalysis, most notably towards new reaction mechanisms. Frequently, ArMs …

Carbon capture technology is currently considered one of the promising technologies to
mitigate atmospheric CO 2 concentration. CO 2 capture and utilization (CCU) captures …