Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

There is conflicting evidence regarding the effect of raised body mass index (BMI) on the
outcome of assisted reproductive technology. In particular, there is insufficient evidence to …

The recent and rapid worldwide increase in non-communicable diseases challenges the
assumption that genetic factors are the primary contributors to such diseases. A new concept …

Proper placental development and function are central to the health of both the mother and
the fetus during pregnancy. A critical component of healthy placental function is the proper …

The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …

Epidemiology formed the basis of 'the Barker hypothesis', the concept of 'developmental
programming'and today's discipline of the Developmental Origins of Health and Disease …

The placenta is vital for mammalian development and a key determinant of life‐long health.
It is the interface between the mother and fetus and is responsible for transporting the …

Obesity of women at conception is increasing, a condition associated with offspring obesity.
We hypothesized that maternal obesity increases placental fatty acid transporter (FATP) …

Maternal obesity can profoundly affect offspring phenotype and predisposition to obesity and
metabolic disease. Carefully controlled studies in precocial and altricial mammalian species …

Insulin resistance and obesity are components of the metabolic syndrome that includes
development of cardiovascular disease and diabetes with advancing age. The thrifty …