Among many achievements in the neurodegeneration field in the past decade, two require
special attention due to the huge impact on our understanding of molecular and cellular …

This review discusses the structure and function of molecular chaperones, with emphasis on
their role in rescuing misfolded proteins. It also includes a discussion of the diseases in …

Environmentally induced periods of heat stress decrease productivity with devastating
economic consequences to global animal agriculture. Heat stress can be defined as a …

Heat shock proteins (HSPs) are a type of functionally related proteins present in all living
organisms, both prokaryotes and eukaryotes. They play essential roles in protein–protein …

Protein aggregation is a hallmark of neurodegenerative diseases. However, the mechanism
that induces pathogenic aggregation is not well understood. Recently, it has emerged that …

Gene expression profiling of human substantia nigra pars compacta (SNpc) from
Parkinson's disease (PD) patients, was examined employing high density microarrays. We …

Neurodegenerative diseases are progressive disorders of the nervous system that affect
specific cellular populations in the central and peripheral nervous systems. Although most …

In both genetic and idiopathic forms of Parkinson's disease (PD), considerable evidence
supports the involvement of α‐synuclein, electron transport chain complex I, protein …

Parkinson's disease is a common neurodegenerative disease characterized by the loss of
dopaminergic neurons in the substantia nigra pars compacta and the accumulation of the …

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that leads to loss of motor
function and early death. About 5% of cases are inherited, with the majority of identified …