Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells
persisting after curative intent therapy. The study of large patient cohorts incorporating …

Recently, chimeric antigen receptor (CAR)-T cell therapy has shown great promise in
treating haematological malignancies,,,,,–. However, CAR-T cell therapy currently has …

Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …

Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …

Clearance of apoptotic cells by macrophages prevents excessive inflammation and supports
immune tolerance. Here, we examined the effect of blocking apoptotic cell clearance on anti …

There is a current imperative to unravel the hierarchy of molecular pathways that drive the
transition of early to established disease in rheumatoid arthritis (RA). Herein, we report a …

Integrated multi-omics evaluation of 823 tumors from advanced renal cell carcinoma (RCC)
patients identifies molecular subsets associated with differential clinical outcomes to …

Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …

Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind
tumour progression and metastasis, making them attractive cancer targets. However …

Immune checkpoint inhibitors targeting the PD-1/PD-L1 axis lead to durable clinical
responses in subsets of cancer patients across multiple indications, including non-small cell …