Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays critical roles in
integrin-mediated signal transductions and also participates in signaling by other cell …

There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

FAK is a tyrosine kinase overexpressed in cancer cells and plays an important role in the
progression of tumors to a malignant phenotype. Except for its typical role as a cytoplasmic …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

Neurofibromatosis type II (NF2) is a tumor predisposition syndrome characterized by the
development of distinctive nervous system lesions. NF2 results from loss-of-function …

The control of organ (or organism) size is a fundamental aspect of life that has long captured
human imagination. What makes an elephant grow a million times larger than a mouse …

Regulation of integrin affinity (activation) is essential for metazoan development and for
many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to …