The neurobiological basis of narcolepsy
CE Mahoney, A Cogswell, IJ Koralnik… - Nature Reviews …, 2019 - nature.com
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …
Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons
The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors,
including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of …
including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of …
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease
S Mostafavi, C Gaiteri, SE Sullivan, CC White… - Nature …, 2018 - nature.com
There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …
a major contributor to aging-related cognitive decline. Here we report the construction and …
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
JM Lane, J Liang, I Vlasac, SG Anderson… - Nature …, 2017 - nature.com
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
DW Kim, PW Washington, ZQ Wang, SH Lin… - Nature …, 2020 - nature.com
The hypothalamus is a central regulator of many innate behaviors essential for survival, but
the molecular mechanisms controlling hypothalamic patterning and cell fate specification …
the molecular mechanisms controlling hypothalamic patterning and cell fate specification …
Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy
Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association
with the HLA DQB1* 06: 02/DQA1* 01: 02 (98% vs. 25%) heterodimer (DQ0602), T cell …
with the HLA DQB1* 06: 02/DQA1* 01: 02 (98% vs. 25%) heterodimer (DQ0602), T cell …
Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour
The hypothalamus is among the most phylogenetically conserved regions in the vertebrate
brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By …
brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By …
Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss
Molecular and cellular processes in neurons are critical for sensing and responding to
energy deficit states, such as during weight-loss. Agouti related protein (AGRP)-expressing …
energy deficit states, such as during weight-loss. Agouti related protein (AGRP)-expressing …