Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …

Oxidative stress and inflammation play a critical role in the initiation and progression of age‐
related ocular abnormalities as cataract, glaucoma, diabetic retinopathy, and macular …

Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy.
Studies in experimental animal models of diabetes strongly implicate oxidant species as a …

Reactive oxygen species (ROS) are generated as by-products of aerobic respiration and
metabolism. Mammalian cells have evolved a variety of enzymatic mechanisms to control …

Tyrosinase, also known as polyphenol oxidase, is a copper-containing enzyme, which is
widely distributed in microorganisms, animals, and plants. Nowadays mushroom tyrosinase …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls
the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2, 3, 7, 8 …

The radiation-induced fibroatrophic process (RIF) constitutes a late, local and unavoidable
sequela to high-dose radiotherapy, traditionally considered irreversible. Today, this process …

Replicative senescence of human diploid fibroblasts (HDFs) or melanocytes is caused by
the exhaustion of their proliferative potential. Stress-induced premature senescence (SIPS) …

Interest in the toxicological aspects of oxidative stress has grown in recent years, and
research has become increasingly focused on the mechanistic aspects of oxidative damage …