Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Genome engineering technology offers unparalleled potential for modifying human and
nonhuman genomes. In humans, it holds the promise of curing genetic disease, while in …

Mutations of the mitochondrial genome (mtDNA) underlie a substantial portion of
mitochondrial disease burden. These disorders are currently incurable and effectively …

Inherited mitochondrial DNA (mtDNA) diseases were discovered 30 years ago, and their
characterization has provided a new perspective on the etiology of the common metabolic …

The unorthodox genetics of the mtDNA is providing new perspectives on the etiology of the
common “complex” diseases. The maternally inherited mtDNA codes for essential energy …

Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell
nuclear transfer (SCNT) has been envisioned as an approach for generating patient …

Maternally inherited mitochondrial (mt) DNA mutations can cause fatal or severely
debilitating syndromes in children,,, with disease severity dependent on the specific gene …

Mitochondrial diseases are among the most common and most complex of all inherited
genetic diseases. The involvement of both the mitochondrial and nuclear genome presents …