For the optimal resorption of mineralized bone matrix, osteoclasts require the generation of
the ruffled border and acidic resorption lacuna through lysosomal trafficking and exocytosis …

Osteoporosis is one of the most common metabolic bone disease among pre-and
postmenopausal women. As the precursors of osteoclast cells, circulating monocytes play …

Background Ossification of ligamentum flavum (OLF) is a hidden, indolent disease condition
with variable unexplained etiology and pathology. Growing evidences show a correlation …

Many statistical machine approaches could ultimately highlight novel features of the etiology
of complex diseases by analyzing multi-omics data. However, they are sensitive to some …

To identify the critical genes and pathways that related to OP development in male AS
patients, bioinformatic gene analysis and qRT-PCR validation were performed. SBNO2 and …

Bone remodeling is a fine-tuned process principally regulated by a cascade triggered by
interaction of receptor activator of NF-κB (RANK) and RANK ligand (RANKL). Excessive …

Background Primary osteoporosis is a systemic skeletal disease characterized by reduced
bone mass and vulnerability to fractures. The genetics of osteoporosis in the Chinese …

Background: Osteoporosis is a gradual and systemic skeletal disease with a low bone mass
and degradation of bone structures. The condition occurs even in the premenopausal stage …

Many statistical machine approaches can identify novel features of the etiology of complex
diseases by analyzing multi-omics data. However, they are sensitive to some deviations in …