Natural killer (NK) cells are important innate effector cells that are well described in their
ability to kill virally-infected cells and tumors. However, there is increasing appreciation for …

Repeated infections by Plasmodium falciparum result in a humoral response that could
reduce disease symptoms and prevent the development of clinical malaria. The principal …

A highly protective vaccine will greatly facilitate achieving and sustaining malaria
elimination. Understanding mechanisms of antibody-mediated immunity is crucial for …

This study on severe malarial anemia (SMA: Hb< 6.0 g/dL), a leading global cause of
childhood morbidity and mortality, compares the entire expressed whole blood host …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated coronavirus
disease 2019 (COVID-19) pandemic has been the subject of a large number of studies in …

Background Genetic polymorphisms in the human immune system modulate susceptibility to
malaria. However, there is a paucity of data on the contribution of immunogenetic variants to …

Natural killer (NK) cells play an important role in the surveillance of viral infections and
cancer. NK cell antibody-dependent cellular cytotoxicity (ADCC) and direct cytotoxicity are …

Controlled human malaria challenge studies in semi-immune volunteers provide an
unparalleled opportunity to robustly identify mechanistic correlates of protection. We …

This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene
encoding R131H FcgRIIA variants and in the FCGR3B gene (108G> C, 114C> T, 194 A> G …

The binding of immunoglobulin (Ig) to Fc gamma receptors (FcgR) at the immune cell
surface is an important step to initiate immunological defense against malaria. However …